CT afferents
نویسنده
چکیده
Do you have a ‘scientific hero’ — if so, who and why? I would mention Max Perutz for his influence on my career shift from medicine toward molecular biology. Reading about his work at the time revealed my genuine interest toward biology. Perutz was a brilliant scientist, a founding member of modern molecular biology in Europe and a great mentor who knew how to inspire young scientists toward pursuing a career in science. His book I Wish I’d Made You Angry Earlier is a good story about science, passion and creative power that reveals scientific research to be the most exciting profession.
منابع مشابه
Vicarious responses to social touch in posterior insular cortex are tuned to pleasant caressing speeds.
BACKGROUND Affective touch carries strong significance for social mammals, including humans. Gentle, dynamic touch of a kind that occurs during social interactions is preferentially encoded by a distinct neural pathway involving tactile C (CT) afferents, a type of unmyelinated afferent nerve found exclusively in hairy skin. CT afferents increase firing when the skin is stroked at a pleasant, ca...
متن کاملHuman C-tactile afferents are tuned to the temperature of a skin-stroking caress.
Human C-tactile (CT) afferents respond vigorously to gentle skin stroking and have gained attention for their importance in social touch. Pharmacogenetic activation of the mouse CT equivalent has positively reinforcing, anxiolytic effects, suggesting a role in grooming and affiliative behavior. We recorded from single CT axons in human participants, using the technique of microneurography, and ...
متن کاملTactile C fibers and their contributions to pleasant sensations and to tactile allodynia
In humans converging evidence indicates that affective aspects of touch are signaled by low threshold mechanoreceptive C tactile (CT) afferents. Analyses of electrophysiological recordings, psychophysical studies in denervated subjects, and functional brain imaging, all indicate that CT primary afferents contribute to pleasant touch and provide an important sensory underpinning of social behavi...
متن کاملA Pathway for Pleasant Touch Linking Peripheral Receptors to Central Processing and Hedonic Experience
This thesis investigates the mechanisms underpinning pleasant touch, describes a pathway from peripheral nerve endings in the skin to the insular cortex, and relates these findings to the subjective hedonic experience of touch. In Paper I, the relationship between primary afferent encoding and perception of pleasantness was investigated by combining microneurography recordings from human mechan...
متن کاملThe role of the human C-tactile system in affective somatosensation and pain
Affective touch perception in humans is a complex construct of input from mechanoreceptive afferents, current homeostatic state and contextual factors. Previously, a relationship has been identified between the pleasantness perception of soft skin stroking and the firing rate of unmyelinated C-lowthreshold mechanoreceptive afferents (C-LTMRs) known as C-tactile (CT) afferents in humans. This re...
متن کاملLow threshold unmyelinated mechanoafferents can modulate pain
BACKGROUND Human, hairy skin contains a subgroup of C-fibers, the C-low threshold mechanoreceptive afferents ((C-LTMR) C-tactile or C-touch (CT) fibers) that are linked with the signaling of affective aspects of human touch. Recent studies suggest an involvement of these afferents in the modulation of pain in healthy volunteers. Small fiber neuropathy (SFN) is associated with a damage of C-fibe...
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ورودعنوان ژورنال:
- Current Biology
دوره 22 شماره
صفحات -
تاریخ انتشار 2012